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Charles V, the Holy Roman Empire, was born in County of Flanders
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Charles V inherits the Netherlands, Belgium and Luxembourg when he succeeded his father, Philip the Handsome, at age six.
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When Charles came of age as duke of Burgundy in 1515, he took control of the Netherlands
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When Ferdinand I died, he gave control of Aragon and Castile to Charles
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Charles was crowned king of Brussels as Charles I of Aragon and Castile
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Charles arrives in Spain to institute a government a little better than foreign rule, under Burgundian influence. He stayed there for two and a half years.
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Charles was elected king of Germany, succeeding his grandfather Emperor Maximilian I. This is what caused him to leave Spain and leave behind restless and dissatisfied people.
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Charles is officially crowned king of Germany in Aachen, also assuming the title of Holy Roman Emperor.
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Before Martin Luther had to defend his doctrines, the imperial Diet got together in Worms. This was a challenge to him, seeing as Luther refused to recant his writings. Charles wrote up the Edict of Worms, rejected Luther's doctrines, and basically declared war on Protestantism.
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Charles's teacher, Adrian of Utrecht, becomes Pope Adrian VI. He tried to reconcile Francis I and Charles V but it didn't work.
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Charles defeats Francis I at the battle of Povia. He takes the king prisoner and ensured Spanish supremacy in Italy.
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Charles's son, Philip, becomes the duchy of Milan.
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Charles V, Holy Roman Emperor, dies of malaria.