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The era of the Roman Empire had just begun Rome had found a new taste for blood and saw Cathrage as a huge threat to their expansion.
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Rome wanted to gain control of Sicily but Sicily was in control of Carthage.
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After Rome's attack and victory on Sicily, it turned it into a harbor ready for what ever was to come their way making them feel like they could take down Cathrage.
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In full charge, Rome invades the islands of Sicily in a string of wars to take it over called the Punic war
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Between 218 and 202 BC Carthage decided to take control of Spain following the First Punic War. Hannibal and Hamilcar led this campaign. Carthage lost again because Carthage neglected to provide Hannibal with resources and reinforcements. Hannibal was compelled to return and defend Carthage after Rome attacked it. Rome destroyed Carthage once more, taking away everything of its splendor. Rome therefore ruled Carthage with pride.
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Carthage, a city in Africa, faced constant attacks from local tribes between 149 and 146 BC. The Carthaginians were unable to cross the Roman borders, leaving them vulnerable to pillaging.
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In 146 BC, Carthage decided to defend itself against the invaders, but it was too late. Fearing Carthage's power, Rome destroyed the city, alleging treaty violations and jealousy as the cause. This marked the end of the hostility between the two great powers. But it also meant the end of Cathrage as a civilization.