Byzantine Empire By Patricia Avendano 527 Justinian became the leader of the Byzantine Empire 532 Church named Hagia Sophia was destroyed in riots that swept Constantinople 542 Bubonic Plague the worst year of the plague. 565 Justinian Died Jun 1, 626 Persians and Avars struck against Constinople Jul 1, 1043 Russians attempt invasion three times Aug 1, 1453 Constantinople Falls to the Turks Mar 2, 2022 Empress Theadora died, Justinian's wife