Byzantine Empire By brotherbear05 527 Justinian became the leader of Byzantine empire 532 The Hagia Sophia was destroyed, Byzantine empire rebuilt it. 542 The worst year of the Plague, 10,000 people were dying everyday 565 Justinian died, the Byzantine empire rebuilt itself. Feb 25, 626 the persians and avars struck against constantinople itself. Mar 25, 1043 russians attempted invasions, the turls took over the muslim world and fought their way into the Byzantine empire Jun 16, 1453 constantinople finally fell to the ottoman turks Mar 2, 2022 Justinian's wife died and afterwards he was so depressed he passed no more major laws