Byzantine Empire By Bubblegoespop 527 Justinian becomes the ruler of Byzantine Empire 532 Hagia Sophia was rebuilt by Justinian 542 Justinian Plague (worst year for it) 565 Justinian dies and his empire has a lot of set backs Jan 1, 626 Persians and Avars struck against Constantinople. The Empire began to crumble Jan 1, 1043 Turks started to take over slowly Mar 25, 1453 Empire finally fell to Ottoman Turks Mar 2, 2022 Justinian's wife died