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The Battle of Panipat, on April 21, 1526, marks the beginning of the Mughal Empire. The forces of Babur, a Central Asian ruler who was descended from the Mongol conqueror Genghis Khan, defeat the Lodi Empire of Northern India.
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Due to instability within the empire, Babur's death in 1530 leads to difficulties with his son Humayun's succession.
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Mahdi Khwaja, and, though they are defeated, it signals Humayun's weakness. Humayun gains the throne in 1531.
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Sher Shah Suri, the leader of the rival Sur dynasty, drives Humayun out of India and seizes power in 1540. Humayun takes refuge with the Safavid rulers in Persia, which serves to create a strong bond with the two dynasties.
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On July 23, 1555, Humayun takes advantage of the deaths of both Sher Shah Suri and his son and successor, Islam Shah, to march an army provided by his Persian allies back to India
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On January 27, 1556, shortly after retaking power, Humayun stops for daily prayer in the middle of carrying books down a flight of stairs and trips. He is fatally injured and dies three days later.
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On November 5, 1556, under Bairam Khan, the Mughal army defeats the Surs and solidifies Akbar's control
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On January 31, 1561, under the guidance of his mother and other supporters, Akbar strips Bairam Khan of the regency, and Khan is assassinated on a journey to Mecca. Akbar is now in full control of the empire