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The Han dynasty collapses because of many years of internal conflict within the government.
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The Huns threatened to attack Rome, and were bribed so they wouldn't. They accepted payment, but still attacked. This left Rome vulnerable for looting by vandals one year later.
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Romulus Augustulus is killed by the barbarian general Odoacer, who will rule Rome.
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After the Huns came in and and reduced the power of the empire a military comander in the middle of the seventh century recived the empire, but after his death the empire just completly fell apart. North India would then not be reunited for hundreds of years.
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The Gupta empire was mostly destroyed after the invasion and constant attack of the Huns. This may not destoryed the empire itself, but it extremly weakened the empire, which caused it's demise.