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In 3500, the first sumerian writing was invented. It was the pictographs.
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In 3000BC, the first wheel was invented in Mesopotamia.
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In 2300BC, the first empire was created because Sargon the Great started to conquer that place.
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In 2220BC, the empire reaches it's hight.
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The city of Ur becomes the center of power of Mesopotamia
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King Hammurabi conquers a very great empire.
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Babylon is conquered by the Kassites and is also ruled for 400 years.
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Nomadic peoples such as the Arameans and the Chaldeans overrun much of Mesopotamia.