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The last roman emperor, Romulus, is overthrown by german barbarian invaders. Rome had grown much to big and due to problems like debt, inflation, invaders, too much land and civil unrest, it collapsed.
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The black death (bubonic plague) reaches Europe, dooming one third of the population
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Johannas Gutenberg invents the printing press, kicking off the information age.
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DaVinci completes the Mona Lisa, a painting that will go on to become one of if not the best known painting in the world. It will be stolen several times during its life.
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Copernicus publishes a book on his findings placing the sun at the center of the universe, rather than the earth. Catholic church goes crazy.
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The catholic church begins a movement to stop the spread of Protestantism, which they viewed as dangerous to the catholic church. Those who went against the church were brutally punished.
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William Shakespeare is born in Stratford upon Avon in 1564. He will become on of the best known playwrights of the millennium.
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Isaac Newton publishes his book "Mathematical Principles of Natural Philosophy" breaking down many of his findings from throughout his lifetime. Again, Catholic church mad.