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A triple alliance is formed between the cities of Tenochtitlan, Texcoco and Tlacopan and creates the foundation for the Aztec Empire.
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Columbus reaches the Americas.
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The Treaty of Tordesillas is signed and the Americas are divided into the Spanish Empire and the Portuguese Empire.
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Columbus meets advanced traders who are likely to be Mayan.
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The land discovered by Columbus was named 'America' by cartographer Martin Waldseemüller in honour of Amerigo Vespucci.
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In the Francisco Hernández de Córdoba expedition, three ships explore the Yucatan. A multitude of Spanish people are killed in skirmishes.
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Cortes and his men fight Maya of Potochan and after winning, Cortes is gifted many things including an enslaved girl called Malinali but is better known as Malinche, Cortes' precious interpreter and the mother of one of his children.
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Cortes and his allies fight the Aztecs and Montezuma, the Aztec ruler, is killed during this time. Cortes and his allies are then leave Tenochtitlan. The bubonic plague spreads through Tenochtitlan now as well and this causes thousands of deaths.
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The Spaniards return to Tenochtitlan and besiege it as well as cut off the water to it. They also attempt to enter the city but end up making the decision of destroying it. The Spanish successfully destroy the city and come out victorious in the battle for Tenochtitlan.
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Francisco Pizarro, the Spanish conquistador, discovered the Inca Empire.
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Francisco Pizzaro return to the Inca Empire with a small army and captures the Inca ruler. The empire's capital, Cuzco, is owned by the Spanish in the following year.
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The entirety of the Inca Empire is defeated by the Spanish and the resistance to Spanish colonisation in South America is put to an end.