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The plague, after spreading through India, Asia, Africa and Europe, entered England in 1348. This plague severely effected England at the time killing many people and spreading or creating new "solutions" which they attempted to stop the plague with.
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Gutenburg finishes the first copies of The Bible using his printing press. This helped the bible become more widely available and spread throughout. It allowed those less fortunate to be able to read and interpret the bible on their own.
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Columbus makes his voyage to the Americas where he finds native Americans and discovers new territory for Spain and eventually the rest of the world. This leads to many future events in the New World fueled by European interference.
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Vasco da Gama was the first to sail around Africa and reach India from Europe via the Cape of Good Hope. He landed and was able to trade in locales which had been what Europeans were trying to accomplish.
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Leonardo Da Vinci started painting the Mona Lisa in 1503. It later became famous due to various circumstances throughout the years.
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Machiavelli began writing the prince as a response to his expulsion from political service. The book represents his efforts to provide political guidance based on history and experience.
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Martin Luther wrote his 95 thesis, containing writings about the power and efficiency of indulgences. These theses started the beginning for the Protestant Reformation.
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Galileo constructed his first telescope in 1609. It was able to see Jupiter's biggest satellites along with Venus' phases and hills plus valleys of the moon.