- 
  
  Verrazzand, sailing for France discovers New York Harbor
 - 
  
  Frenchman Jacques Cartier navigate the St. Lawrence River names an Island Along the River Montreal
 - 
  
  Jamestown is founded on the coast of Virginia by 100 English settlers
 - 
  
  French explorer, Samuel de Champlain, founds thcolony of Quebec
 - 
  
  An epidemic of smallpox, brought by Europeans, kills many native Americans on the New England coast.
 - 
  
  Pilgrims from England found an English Colony in Plymouth, Massachusetts.
 - 
  
  Henry Husdon, exploring for the Netherlands, claims land that will become New Netherland
 - 
  
  The Duke of York drives out the Durth in New Netherland. The Duke of York claims the colony for England and renames it New York
 - 
  
  King Phillip's War begins in Colonial villages of Massachusetts, between colonists and Native Americans
 - 
  
  War between the British and the French, know as the French and Indian war. The war is fought over disputed lands claims in the Ohio Valley
 - 
  
  Sieur de la Salle explores the lowe Mississippi Valley river, and claims the valley for France and names it Louisiana in honor of the French King Louis XIV