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The black death arrives on some ships to Italy, resulting in the death of ~1/3 of Europe.
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With the inventing of the printing press, printed word could be spread much easier and much better than before
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Christopher Columbus sails off for India but ends up landing in North America, more specifically, in the Caribbean.
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A large and highly detailed statue is finished by Michealangelo.
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The large painting School of Athens is completed by Raphael
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Martin Luther nails his 95 theses to a church door, sparking the Protestant Reformation
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Galileo finishes his telescope, allowing him to gain more concrete evidence for the heliocentric theory of the universe
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The great playwright, having written over 35 plays in his lifetime
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Isaac Newton publishes the Principia, containing his laws of gravity and motion, starting modern physics
