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The printing press was created, increasing the spread of knowledge across Europe.
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Europeans arrived in America, yet 54 million people were already there; they split into separate tribes, created over 2,000 different languages, and developed many diversities.
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Columbus returned to Hispaniola with numerous amounts of men, horses, swine and cattle. The horses traveled spreading to as far as Canada. North American Indian tribes used the horses to improve their way of life.
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The Treaty of Tordesillas was created between Spain and Portugal. This divided The New World, Africa/Europe/Asia, evenly between both countries.
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The Aztecs attacked the Spanish, driving them away. Cortes, a year later, then surrounded the city, in hopes they would surrender with lack of essentials.
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Bartolome de Las Casas wrote The Destruction of the Indies telling the end of the Natives and to protest against the Spanish in The New World. He wrote about what the Spanish did not include in their writings.