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Columbus reached North America. He had though he had arrived at the East Indies, but he really was in the Bahamas.
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This was the beginning of the Slave Trade, which lasted from the 1500s to the late 1800s.
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The Spanish conquest was led by Hernando Cortes while the Aztecs were under Montezuma's rule. The Aztecs were developing and spreading but were stopped by Cortes' army, armed with advanced technology and disease.
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The Incan Army was extremely larger than Pizarro's army, but he overcame this by using native allies and advanced weaponry.
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Jamestown was the first successful English colony in North America.
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This war lasted 7 years, and when it ended a peace treaty was signed. It was fought between Great Britain and France. Both countries suffered financially after the war.