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Christopher Columbus was attempting to reach Asia, by using an alternate route than other explorers. He thought that he had reached India, but he had actually landed upon an island he named San Salvador.
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The first enslaved Africans arrived in Hispaniola.
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Cortes was able to conquer the Aztec Empire despite the fact that he had few men. He was able to make alliances with other natives, but most of all the Europeans brought diseases which killed several Natives.
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Fransico Pizzaro was able to conquer the Incan Empire by setting up his troops ready for ambush near a city of Cajamarca. Altough the Incan ruler, Atahualapa, offered to give them a room filled with gold. After the deal, Atahualapa was still killed.
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Jamestown was the first permanent American settlement.
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At the peak of Plymouth colony, it expanded to most of Massacusetts. During the time at Plymouth, the Americans were aided by a Native American, Squanto.
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The French and Inidan War was known as the Seven Year war for it lasted for such a long time. The first President of the United States, George Washington, was also part of this battle.