Proved that blood was found in the arteries by doing experiments on animals. He set the path for future centuries of discovery.
Jan 1, 1200
Pulmonary circulation was discoverd in the mid-1200's. which is how the blood flows to anf from the lungs,
Fabricius makes the first drawings of vein valves and publishes his work ON THE VALVES IN VEINS.
William Harvey describes that blood is pumped by the heart and circulates within the body.
Red Blood Cells
The first person to observe and describe red blood cells is Jan Swammerdam.
Marcello Malpighi observes the capillary system, the network of fine vessels that connect the veins and the arteries.
Animal Blood Transfusion
The first blood transfusion on animals is made with dogs, by Richard Lower.
Red Blood cells
Anton van Leeuwenhoek further observes red blood cells. He is widley credited with the discovery.
William Hewson researches blood coagulation and isolates a substance from plasma, fibrogen.
Human Blood Transfusion
Philip Syng Physick performs the first human-to- human blood transfusion, but his work is not published.
Human Blood Transfusion
James Blundell performs the frist recorded human blood transfusion. He injects a patient with donated blood from several people but, ater improving the patient dies.
Sir William Osler studies cell fragments, later known as platelets, that make up clots formed in blood vesles.
Karl Landsteine discovers three main human blood groups A, B, and C, later known as O. He detects different antibodies in groups A & B that are both in C (O).
AB Blood type
Alfred von Decastello and Adriano Sturli discover a fourth blood group (AB). It causes agglutination in the red cells of both A & B.
Ludvig Hektoen recommends blood tests for donors and recipients for signs of incompatibility before transfusion.
Albert Hustin and Luis Agote discover that adding sodium citrate to blood will prevents clotting.
Dr. Richard discovers that citrated blood can be stored in the refrigerator and stored for a few days before being transfused.
Francis Peyton Rous and J.R. Turner make a citrate-glucose solution that allows blood to be longer and still be good for a transfusion.
Oswald Robertson establishes the first blood depot, helping with casualties during WW1.
Blood Doner Service
Percy Lane Oliver starts a blood doner service out of his home. he take measyres to ensure the saftey but screening for diseses.
Cadaver Blood Transfusions
Dr. Serge Yudin tests transfusing humans with cadaver blood. His discoveris are a sucess and he esuscitates a young man.
A group of anesthesiologists organize a transfusion service and are the first to begin storing citrated blood and utilizing it for transfusions within a hospital setting in the U.S.
Barcelona Blood-Transfusion Service
Established by Federico Duran-Jorda, the service collects blood, tests it, orginizes by group, preserves it, and takes it to front line hospitals during the Spanish Civil war.
Dr. Bernard Fantus comes up with the term "Blood bank" to describe blood donation. He establishes one at a hospital in Chicago.
Charles Drew developes a way to separate and preserve blood plasma. He performs tests, and store plasma for the Red Cross.
The Amrican Red Cross establishes a blood donating service to contribute and help the war.
American Association of Blood Banks
Community blood banks uniite to make a national network of blood banks. (AABB)
Carl W. Walter makes a plastic bag that can be used to store/ collect blood. Before this blood had to be stored in a glass container.
Max Perutz uses X-ray crystallography to unravel the structure of hemoglobin, which is the protein in red blood cells responsible for carrying oxygen.
Bood banking industry was regulated by the Division of Biologics Standards (DBS) but then transferd to the Food and Drug Administration (FDS)
Dr. Baruch Blumberg develops a test to find hepatitis B antibodies which identifies infected donors; the test is mandated by the FDA.
The first cases of AIDS (Acquired Immune Deficiency Syndrome) are reported; before it was renamed AIDS it was GRID (Gay-related Immunodeficiency Disease).
Researchers in france isolate the virus that causes AIDS. They identify it in the swollen lymph node and label it LAV (lymphadenopathy-associated virus).
AIDS- (virus discovery)
Robert Gallo identifies the virus that causes AIDS, he calls it HTLV III (human T-cell lymphotropic virus).
Many Americans are infected with AIDS from blood transfusions, the first blood-screening test to detect the presence or absence of HIV antibodies is crated; the test is adopted by American blood banks.
More tests are developed and experimented to screen donated blood for infectious diseases.