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Justinian and Theadora's reigns was the height of the Byzantine empire. During this year of course. That was the year the empire was at it's most powerful.
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Muslims were attacking none other than the city of Constantinople. After came the fall of Constantinople. Thety also had north africa to them.
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This was when Alexander the great had the Roman empire split into two seperate empires. The western empire was constantly attacked as for the eastern empire it wasn't attacked as much as the other.
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Crusaders were attacking around this time. By the 1300 Byzantine was only Constantinople. Which was also and included part of greece.
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It fell to the ottoman truks.