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In 1492 Columbus sailed the ocean blue. His landing in the Caribbean was a significant event in relation to imperialism. He sailed for the Spanish throne, in attempt to grow their empires sphere to influence.
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In 1521, in a brutal struggle to be be alive, Cortes and his Indian allies captured and demolished Tenochtitlan. It was a battle with a lot of killings.
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In the Mid-1500 treasure fleets sailed each year to Spain or the Spanish Philippines loaded with gold and silver. This wealth caused a lot of controversy with the wealthy and the poor.
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Tons of silver from the Potosi region of Peru and Bolivia filled Spanish treasure ships and with this wealth Spain became Europe's greatest source of money and power. Europe used these as things to trade and swap for other things they needed or wanted.
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The Spanish moved north, making claims to Texas and Florida. English and Dutch maintained colonies on the East coast. Native Americans in the colonies entered the conflict hoping to play the Europeans.
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Competition got fierce in the Caribbean, as Europe nations fought to win sugar cane reproducing colonies. That gained the winners a pretty penny. It gave them good rep and money off of there wins.