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Period: 430 BCE to
First Attempts at Variolization
Variolation was used a a major way to prevent disease before vaccination, either through the grafting of smallpox scaps onto the skin of an uninfected person or coming into contact with an infected person or infected matter in a controlled setting. -
First "Modern" Vaccination
Edward Jenner inoculated an 8-year-old boy, James Phipps, with matter from cowpox lesions in hopes of making him immune to smallpox. -
Second Inoculation of James Phipps
Edward Jenner inoculated the boy again in July. This time, though, he used matter from a smallpox lesion. When the boy developed no symptoms, Jenner assumed that the protection was complete. -
The Death of Edward Jenner
Edward Jenner was found dying in his study after having a massive stroke. -
Pasteur Injects Child with Experimental Rabies Vaccine
Louis Pasteur and his colleagues injected the first of 14 daily doses of rabies vaccine into a 9-year-old boy, Joseph Meister, after he was severely bitten by a rabid dog. -
First Attempts at Tetanus Antitoxin
Edmond Nocard demonstrated the protection and immunization of tetanus by using passively transferred antitoxin as well as deactivating the bacteria and spores. -
FDA Foundation
The FDA was founded in order to regulate the food and drug commerce. They also set into play regulations for vaccine development and whether they can or cannot be used on the human population depending on studies done on the medicine. -
Licensure of the First IPV Vaccine
The first inactivated polio vaccine was created by Jonas Salk, and was licensed on the same day that the results of it's testing were released. Salk originally tested the vaccine on him and his family. -
Period: to
Research is Conducted on a Polio Vaccine
Vaccines are developed for all 3 strains of polio, and saw widespread use across the world in an attempt to eradicate poliovirus. -
WHA Announces the Eradication of Smallpox
The World Health Assembly announces that the world is free from smallpox and reccomended a cease of vaccination. -
MMRV Vaccination Licesure
The measles, mumps, rubella, and varcella vaccine was licensed and became one of the recommended vaccinations for children. -
Pfizer Covid-19 Vaccine Given Emergency Use Authorization
Pfizer's Covid-19 vaccine was given emergency use authorization by the FDA and was distributed around the world.