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A triple alliance is forged between the cities of Tenochtitlan, Texcoco and Tlacopan. This cements the power of the Aztec Empire.
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Christopher Columbus arrives in the Americas, landing in the Bahamas, Cuba and Hispaniola in the caribbean.
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The Treaty of Tordes was is signed. In it Pope Alexander VI grants all lands to the west of a line in the Atlantic Ocean to Spain, and all lands to the east of the line to Portugal.
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Montezuma becomes the Aztec ruler.
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"America" is first named by the cartographer Martin Waldseemüller, in honour of the explorer Amerigo Vespucci.
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Hernandez de Cordoba begins to explore Yucatan Peninsula and Mexico's east coast.
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Hernán Cortés arrives in the Aztec empire and enters the capital city. Tenochtitlan.
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Aztec in Tenochtitlan are massacred by the Spanish and Montezuma dies. The Spanish are driven out of the city a few months later. A smallpox epidemic sweeps through the region in the same year killing thousands.
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The aztecs are deleated and Tenochtitlan is destroyed after a three-month siege by the Spanish and their allies.