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The Maya were a mesoamerican group of people that developed a writing system.
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The Olmecs were the first major civilization in Mexico.
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The Aztecs were a mesoamerican culture that flerished in 1521 due to war, government issues, disease, etc.
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The Aztecs started their civilization in 1345.
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The Inca empire was the largest in pre-Columbia America.
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In 1430 Azcapotzalco conquered and the Aztecs were put under Azcapotzalcos rule.
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During 1510 lots of floods were occurring that led to a famine.
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The deadly disease smallpox killed Cuitláhuac along with many other Aztec people.
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This is when the Aztec empire fell. The empire fell due to smallpox, unstable government, war, being captured by the Spanish.