Aztec timeline By Lirichio5928 Apr 1, 1325 The Aztecs came to the Valley of Mexico. Apr 1, 1345 Tenochtitlan established. Apr 11, 1492 King Fernand and Queen Isabella capture Granada. Apr 11, 1494 Treaty of Tortesillas Apr 11, 1496 Santo Domingo established by Spanish on Hispaniola Apr 1, 1502 Montezuma becomes leader of Aztecs. He, the leader of Aztec people, was known as The Great Speaker. Apr 11, 1503 Spain begins exporting gold and silver from the Americas. Apr 1, 1519 Cortes arrives in Mexico Apr 1, 1520 Moctezuma killed, Spanish driven out of Tenochtitlan, smallpox outbreak among Aztecs. Apr 11, 1521 Spanish defeate Aztecs.