APUSH Period 1 By jujudyy 1491 Pre-Columban tribes 1492 Columbus discovers America 1494 Treaty of Tordesilla Portuguese + Spanish divide South America. 1517 Protestant Reformation 95 Theses by Martin Luther. 1519 Cortes conquers Mexico 1519-1521. 1532 Pizarro conquers Incas 1540 Coronado explores Southwest 1540-42. 1570 Iroquois Confederacy founded Late 1500s. 1585 Roanoke Colony 1588 England defeats Spanish Armada Reinvigorates English for colonization. 1607 Jamestown