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The overexpansion and insecurity of the Roman Empire led to its eventual downfall in 476, creating a new era in which the most influential empire in Europe was gone.
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In Runnymede on June 15, King John was forced to sign one of the most influential documents ever written that would shape modern law for centuries to come.
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The Black Death began spreading from China in 1348 and would change Europe forever.
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Around 1436, Brunelleschi created the largest dome ever built (at the time) atop the Florence Cathedral.
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Renaissance man Leonardo da Vinci created arguably the most famous painting in history between 1503 and 1506.
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On October 31, 1517, Martin Luther posted the 95 Theses on a church door, sparking the beginning of the Reformation against the Church.