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Romulus Augustus, the last Emperor of the Western Roman Empire, was deposed by Odoacer, a Germanic chieftain.
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The Franks under Clovis defeat the Visigoths in the Battle of Vouillé, forcing them to retreat into Spain
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Justinian I becomes Eastern Roman Emperor. Justinian is best remembered for his Code of Civil Law (529), and expansion of imperial territory retaking Rome from the Ostrogoths.
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Byzantines, under Belisarius, retake North Africa from the Vandals.
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Muhammed is born. Professed receiving revelations from God, which were recorded in the Qur'an, the basis of Islamic theology, in which he is regarded as the most important prophet.
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Last great Roman-Persian War Long conflict leaves both empires exhausted and unable to cope with the newly united Arab armies under Islam in the 630s
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Battle of Nineveh. The Byzantines, under Heraclius, crush the Persians.
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Death of Muhammed. By this point, all of Arabia is Muslim.
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Second Muslim attack on Constantinople, ending in failure. The combined Byzantine–Bulgarian forces stop the Arab threat in Eastern Europe.
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Otto the Great crowned the Holy Roman Emperor.