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Father Alonso de Benavides directed the founding of 10 missions.
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Epidemic in New Mexico killed over 3,000 Native Americans.
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Corpus Christi de la Ysleta established by Antonio de Otermin and Fray Francisco de Ayeta.
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Father Damian Massanet left Barcelona to start a new life in the New World.
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La Salle's expedtiton for the French began.
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One of the first missions in the area La Salle explored failed because of Indian hostility
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San Francisco de los Tejas mission was established by Father Damian Massanet, Alonso de Leon, and Father Francisco Hildgago near where Houston is now.
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Father Damian Massanet burned down the San Francisco de los Tejas mission.
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Jose de Escandon founded and governed over 20 colonies including the Nuestra Senora de los Delores Hacienda.
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The mission San Antonio de Valero, which is now known as The Alamo was founded and built.
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The mission San Jose y San Miguel de Aguayo was created.
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The Franciscans built a mission in Matagorda Bay.
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Three missions had unsuccessful beginnings in East Texas and were relocated to San Antonio.
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Smallpox and Measles were washed out from the Native Americans.