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After the founding of Santa Fe, New Mexico, El Paso became an important place for north-south communication.
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In 1680, the Indians at Santa Fe in northern New Mexico revolted against the Spainsh, causing the settlers there to flee and take refuge in the El Paso area. With the Spanish, some friendly Indian tribes came, who settled along the Rio Grande. The mission on Corpus Christi took place there.
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Damián Massanet and Francisco Hidalgo helped with the founding of the first East Texas mission, College of Santa Cruz de Querétaro.
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After countinued disputes with the Caddos, Manssenet decided to burn the mission and return to Mexico. He was discouraged by his failure.
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In 1699, San Juan Bautista also known as "The Mother of Texas Missions," was founded. Father Hidalgo was involved with this mission.
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In 1718, San Antonio de Valero (the Alamo) was founded in San Antonio.
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In 1720, the San Jose mission was established by Fray Antonio Margil de Jesus.
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Antonio Margil de Jesús founded one of the most sucessful missoins in San Antonio, San José y San Miguel de Aguayo.
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in 1731, San Juan was established on the banks of the San Anonio River.
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Colonists from the Canary Islands established the Villa of San Fernando de Bexar.