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In 1519, Spanish explorer Alfonso Alvarez de Pineda mapped the coast of Texas.
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In 1528, Spanish Explorer Cabez de Vaca shipwrecked off Galveston Island.
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Santa Fe was made the capital of New Mexico in 1610.
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In 1632, the first Texas mission is established near preasent day San Angelo.
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In 1682 the Indian mission towns of Corpus Christi de la Isleta, Nuestra Señora de la Limpia Concepción de Socorro, and San Antonio de Senecú were founded by Tigua, Piro, Tompiro, and Tanoan people who had accompanied the Spanish in flight from the Pueblo Revolt in northern New Mexico
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French explorer La Salle shipwrecked on La Belle, and establishes Fort St. Louis on Garcitas Creek.
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The friars fleed to San Francisco de Tajas.
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In 1716-17, a spanish mission named San Francisco is reestablished.
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Nuestro Padre San Francisco de los Tejas was re-established on the west bank of the Neches River in 1716 as the successor to the Mission Tejas, the mission that had been abandoned in 1693.
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In April, 1718, Don Martin de Alarcon and Padre Fray Antonio de San Buenaventura y Olivares traveled northward to establish another mission settlement which would grow into the city of San Antonio. Thus San Solana became Mission Valero (the Alamo), the first of the chain of five missions that would ultimately be founded along the San Antonio River.
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In 1719, the Spanish establish Presidio La Bahia at Espritu Santo Bay.
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In 1720, a second mission, San Jose y San Miguel de Aguayo, was established downstream on the San Antonio River. A decade later, three missions which had unsuccessful beginnings in East Texas were relocated to San Antonio. Situated at key points along the river, they became known as Missions Concepcion, Espada, and San Juan Capistrano.
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Mission Espíritu Santo established near presidio, on Garcitas Creek.
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1725-Mission Espíritu Santo moved 10 leagues west, to Guadalupe River site, after violence between Spanish and Indians.
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In 1726, mission San Lorenzo was esablished.
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Franciscan missionaries establish Mission Rosario.
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On the morning of March 16, 1758, Mission Santa Cruz de San Sabá, a small, hastily constructed compound enclosed by a wooden palisade, was surrounded by 2000 hostile Indians including Wichita, Comanche, and Caddo warriors.
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Included on El Paso’s Mission Trail today is the Chapel of San Elizario (Elceario). It was not a mission but served the presidio that was moved there from across the river in 1789.