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Over half of the population of Europe was wiped out by the Black Plague. Afterwards, the economy was improved due to survivors inheriting money from their dead relatives, starting the Renaissance.
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The Italian artist, Leonardo Da Vinci, paints a half-length portrait of a woman called The Mona Lisa.
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Michelangelo uses a technique called "fresco" to paint the ceiling of the Sistine Chapel with bright colors.
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Thomas More, a noted Renaissance Humanist, writes "Utopia", a fictional book about political philosophy.
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Martin Luther posts the 95 theses, which protests the ways of the Roman Catholic Church which started the beginning of the Reformation.
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King Henry VIII separates the Church of England from Rome.
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Ignatius of Loyola and six other students at the university of Paris met in Montmartre outside of Paris and called themselves the company of Jesus.
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John Calvin writes a book about Protestant systematic theology called "The Institutes of Christian Religion"
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Protestant nobles led by Knox made Calvinism Scotland's official religion and got rid of the Catholic ruler, Mary Queen of Scots.
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William Shakespeare writes the famous tragedy, "Romeo and Juliet" about two star-crossed lovers who end up killing themselves.
