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Ivan's father, Vasili III dies when Ivan is three years old. Now Ivan is appointed grand prince of Moscow, but he is not in power because his mother is a regent.
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Ivan's mother dies when he is seven years old, he now has no parents, and her role as regent gets replaced by some family members.
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Ivan leads significant military victories into Siberia by overtaking Kazan and Astrakhan, two Tatar strongholds.
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Ivan suffers through a near fatal illness, but makes a full recovery.
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Ivan's beloved wife, Anastasia Romanovna dies several years after Ivan's near fatal illness. This is a drastic change in Ivan's life and causes him to completely change his attitude and style of ruling. He believes that she has been poisoned, and Ivan becomes paranoid and mentally unstable as a result of her death.
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Ivan left Moscow secretly and threatens to renounce his throne. The public went in to panic and begged him to come back. He came back, but only on his own terms that he could have absolute power and punish any he believed were not loyal to him.
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Ivan becomes enraged at his son's pregnant wife for being under dressed, and beats her. This causes her to miscarry.
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It is believed that after an argument stemming from the previous beating of his daughter in law, Ivan the terrible kills his own son accidentally in a fight. Ivan's son would have been heir to the throne.
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