History of Vaccines By chanm348 1500 First mention of Preventative Innoculations about smallpox in writing in China 1796 Edward Jenner proposes the first scientiic method of vaccination 1853 Smallpox vaccinations become mandatory in the UK 1885 Louis Pasteur Develops first live virus vaccine (Rabies) 1892 First Virus Discovered 1920 Development of tuberculosis, diphtheria, tenatnus, whooping cough vaccines 1944 First Vaccine against the Flu 1950 First combination vaccine (DTP-Diphteria,tentanus, whooping cough) 1986 First Genetically engineered vaccine (hepatitis B)