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The Black Plague spreads through Europe killing 75 to 200 million people.
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Leonardo begins paiting one of the world's most famous paintings, the Mona Lisa.
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The great painter, Michelangelo begins his work on the Sistine chapel.
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Thomas Moore writes the book, Utopia.
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Martin Luther posts his 95 complaints against the Catholic Church.
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King Henry VIII breaks away from the Catholic Church, and sets up the Church of England.
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The preacher John Knox returns to Scotland and sets up the Presbyterian Church.
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Ignatius founds the Society of Jesus.
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The great playwrite, William Shakespeare finishes writing Romeo and Juliet.
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John Calvin writes the book The Institutes of Chritian religion.
