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The Medici family becomes the head of the city-state of Florence.
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The Ottoman Empire captures the city of Constantinople, signaling an end to the Byzantine Empire.
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Christopher Columbus
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Michelangelo begins his work on the sculpture David.
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Henry VIII becomes king of England.
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Ferdinand Magellan begins his voyage around the world.
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Elizabeth I becomes Queen of England.
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Galileo discovers the moons of Jupiter.
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