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The Crown Authorizes African Slave trade, a future trade that, along with the Sugar Industry(which it stimulated) would prove to be vital to the economy/political control in Latin America under the Portuguese/Spanish/English/Dutch/French colonists/merchants/nobles.
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Juan Ponce De León founds San Juan after conquering Puerto Rico. Also Discovers Gold. Sugar mills are established on Española.
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First permanent settlement of Santa Marta in what would later be Nueva Granada founded by Rodrigo de Bastidas.
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Governor of Venezuela chosen, after administration established by colonists who were sent by Welsers. Protests in Spain. Dreams of El Dorado and lots of gold. Harsh times for Indians.
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After leaving Cuzco, Pizarro founded the (future) Perú Capital city; Lima.
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Almagro was enfuriated that he failed in his attempt to conquer Chíle, and decided to go to war against Pizarro over jurisdiction of Cuzco, which did not bode well for him.