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The first African American slave arrives in Virginia.
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Slavery becomes illegal in the Northwest Territory. The US constitution states that congress may not ban the slave trade until 1808.
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Eli Whitney's invention of the Cotton Gin increases demands for slave labor
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A federal fugitive slave law is enacted, providing for the return slaves who had escaped and crossed state lines.
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Congress bans slave importation from africa
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Harriet Tubman escapes from slavery and becomes one of the most effective and celebrated leaders of the Underground Railroad.