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In 1501 Spanish settlers brought the first African slaves to the New World
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On March 4, 1513 free africans Juan Garrido and Juan Gonzalez de Leon accompanied Juan Ponce de Leon in his exploration of La Florida
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In mid July the first enslaved Africans were brought to North American by Lucas Vazquez de Allyon expedition; established settlement of San Miguel de Gualdape in present-day Georgia; this is the first European settlement in the geographic United States.
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Panfilo Narvaez attempts to settle near what is now the present day Tampa Bay with 600 people, including slaves. Lack of supplies and hurricans doom venture.
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Four survivors of the doomed Tampa Bay settlement end up in Mexico and the coast of the Pacific Ocean after walking through wilderness for eight years. Estevanico, an African slave, ensures their survival by learning to communicate with natives along the way
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Hernando de Soto explores Florida and much of the present-day southeastern United States with the aid of free and enslaved Africans.
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Saint Augustine, the oldest permanent city in the USA, established by Spain. It is home to over 600 people, including 50 African slaves. Some of these slaves immediately escape into the surrounding wilderness.