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The Louisiana purchase was the first of many lands America obtained and helped start the drive for pioners.
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Their expedition helped to facilitate maps and broaden the understanding of the western world for all the pioneers and settlers to come.
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The Indian removal act leads to the Indians being forced to the west of the Mississippi which removed the danger of Indians for settlers. https://guides.loc.gov/indian-removal-act
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The Trail of tears happened right after the Indian removal act when many Indians had to be forced off of their land or killed whilst trying to protect their land.
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The Oregon Trail was a pioneer trail used to get from the far east to the pacific ocean. This gave people a defined route which made travel easier.
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James Marshal finds gold and thus starts the California gold rush.
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The Mexican-American war got the US many states which again lead to further expansion
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The Homestead act gave land to people who qualified and all the people had to do was improve the land so many people went west to get land and start a new life.
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The Transcontinental railroads were completed by 1869
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And Finally, The Us government in 1890 officially announces that the west has been completely explored.