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Meischer
Meischer isolated "nuclein"' DNA with associated proteins, from the nuclei. He was the first to identify DNA as a distinct molecule. The way this discovery succeeded was Meischer did may investigations, on the cell. He began on the most important part which was the nucleus. Miescher continued to work on nuclein for the rest of his career. -
Chargaff
He discovered two rules that helped lead to the discovery of the double helix structure of DNA. The first rule was that in DNA the number of guanine units equals the number of cytosine units, and the number of adenine units equals the number of thymine units. -
Meselson and Stahl
Meselson and Stahl invented the technique of density gradient centrifugation, which was used centrifugal force to separate molecules based on their densities. They were interested in trying to devise a way to prove or disprove Watson and Cricks model of semi-conservative replication. Meselson and Srahl agreeded to work together on devising the right experiment. By 1957, the two had the experimental proof for the semi-conservative replication of DNA. By this the invented DGC. -
Franklin
Studying DNA, with x-ray diffraction, Franklin and her student made an amazing discovery: They took pictures of DNA and discovered that there were two forms of it a dry "A" form and a wet "B" form. One of their x-ray diffraction pictures of the "B" form of DNA, known a Photgrah51, became famous as critical evidence in identifying the structure of DNA. The photo was acquired through 100 hours of x-ray exposure from a machine Franklin herself had refined. -
Hershey and Chase
Hershey and Chase confirmed that DNA was the biomolecule they carried genetic information. They did an experiment in 1952 that was called the Hershey and Chase Experiment. This experiment set out to determine what composed the genetic material of bacteriophage, which is a virus that infects a bacterium called T2 that effects Escherichia Coli. T2 is just a crystal of DNA and protein must leave E. Coli to make more of itself. -
Watson and Crick
Watson Crick were the only two of may scientist working on figuring out the structure of DNA. California Chemist Linus Pauling suggested an incorrect model at the beginning of 1953, promoting Watson and Crick to try and beat Pauling at his own game. One morning on February 8, they determined that the structure of DNA was a double helix polymer, or a spiral of two DNA strands, each containing a long chain of monomer nucleotides, wound around each other. -
Watson and Crick
In the 1950s, Watson and Crick were only two of many scientist working on figuring out the structure of DNA. California Chemist Linus Pauling suggested an incorrect model at the beginning of 1953, promoting Watson and Crick to try and beat Pauling at his own game. On the morning of February 28, the determined that the structure of DNA was double helix polymer, or a spiral of two of DNA strands, each containing a long chain of monomer nucleotides, wound around each other.
