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DNA through history

  • Gregor Mendel´s pea plants

    Gregor Mendel´s pea plants
    Mendel did groundbreaking work into the theories of heredity. Using simple pea plants, Mendel studied seven basic characteristics of the pea plants. By tracing these characteristics, Mendel discovered three basic laws which governed the passage of a trait from one member of a species to another member of the same species.
  • Period: to

    Classical Genetics

    The history of genetics started with the work of Gregor Mendel.
  • Friedrich Miescher's discovery

     Friedrich Miescher's discovery
    Based on Mendel's studies, Friedrich Miescher discovers a weak acid in the nuclei of white blood cells that today we call DNA
  • Walther Flemming and Mitosis

    Walther Flemming and Mitosis
    Flemming investigated the process of cell division and the distribution of chromosomes to the daughter nuclei, a process he called mitosis. He studied mitosis using the source of biological material as the fins and gills of salamanders.
  • Walter Sutton's theory

    Walter Sutton's theory
    His theory was that the Mendelian laws of inheritance (primary tenets relating to the transmission of hereditary characteristics from parent organisms to their offspring) could be applied to chromosomes at the cellular level of living organisms. This is now known as the Boveri-Sutton chromosome theory.
  • Thomas Morgan's discovery

    Thomas Morgan's discovery
    Morgan was able to demonstrate that genes are carried on chromosomes and are the mechanical basis of heredity. These discoveries formed the basis of the modern science of genetics.
  • Alfred Sturtevant's map

    Alfred Sturtevant's map
    Sturtevant published the world's first genetic map. The idea of gene linkage came to him in a flash one night. Sturtevant realized that genes were linked in a series, and data as to how these genes were linked could be deduced by building the "right" Drosophila mutant.
  • Jean Brachet's discovery

    Jean Brachet's discovery
    Brachet was able to show that DNA was found in chromosomes and that RNA was present in the cytoplasm of all cells.
  • Edward Lawrie Tatum and George Wells Beadle

    Edward Lawrie Tatum and George Wells Beadle
    Both showed that genes control individual steps in metabolism.
  • Avery–MacLeod–McCarty experiment

     Avery–MacLeod–McCarty experiment
    The Avery–MacLeod–McCarty experiment was an experimental demonstration by Oswald Avery, Colin MacLeod, and Maclyn McCarty, that DNA is the substance that causes bacterial transformation.
  • Period: to

    The DNA era

  • Hershey-Chase experiment

    Hershey-Chase experiment
    The Hershey–Chase experiments were a series of experiments by Alfred Hershey and Martha Chase, confirming that DNA was the genetic material, which had first been demonstrated in the 1944 Avery–MacLeod–McCarty experiment.
  • Albert Levan discovery

    Albert Levan discovery
    Albert Levan was the first person to recognize the normal number of human chromosomes, 46, instead of 48, as previously believed.
  • Restriction enzymes

    Restriction enzymes
    Restriction enzymes were discovered in studies of a bacterium, Haemophilus influenzae, enabling scientists to cut and paste DNA
  • Walter Fiers discovery

    Walter Fiers discovery
    Walter Fiers and his team at the Laboratory of Molecular Biology of the University of Ghent were the first to determine the sequence of a gene: the gene for bacteriophage MS2 coat protein.
  • Period: to

    The genomics era

  • Francis Collins and Lap-Chee Tsui

    Francis Collins and Lap-Chee Tsui
    The human gene that encodes the CFTR protein was sequenced by Francis Collins and Lap-Chee Tsui. Defects in this gene cause cystic fibrosis.
  • Human Genome Project

    Human Genome Project
    First draft sequences of the human genome are released simultaneously by the Human Genome Project and Celera Genomics.
  • Successful completion of Human Genome Project

    Successful completion of Human Genome Project
    Successful completion of Human Genome Project with 99% of the genome sequenced to a 99.99%
  • Scientists at The Hospital for Sick Children Brigham, Women’s Hospital and Harvard Medical School discovery

    Scientists at The Hospital for Sick Children Brigham, Women’s Hospital and Harvard Medical School discovery
    Scientists at The Hospital for Sick Children Brigham, Women’s Hospital and Harvard Medical School made the unexpected discovery that significant differences can exist in the overall content of DNA and genes contained in individual genomes.
  • Disorder's discovery

    Disorder's discovery
    Drs. Larry Young and Elizabeth Hammock, of Emory University, using the native vole, traced social behavior traits, such as monogamy, to seeming glitches in DNA that determines when and where a gene turns on.
  • DNA Is Not Destiny

    DNA Is Not Destiny
    The new science of epigenetics rewrites the rules of disease, heredity, and identity.
  • Discovery Could Help Bring Down Price Of DNA Sequencing

    Discovery Could Help Bring Down Price Of DNA Sequencing
    Using a theory based on classical hydrodynamics, a Northwestern University researcher explained the nature of the resistive force that determines the speed of the DNA as it moves through the nanopore, which is just five to 10 nanometers wide. This understanding could help scientists figure out how to slow the DNA down enough to make it readable and usable -- for medical and biotechnology applications, in particular.
  • DNA discovery may help explain cancer

    DNA discovery may help explain cancer
    Taiwanese biologists have discovered a link between a protein-modifying enzyme and a specific gene sequence that could help researchers better understand the consequences of unwanted gene activations and ultimately the cause of some cancers
  • Discovery May Prove Invaluable In Quest For Gene Therapies

    Discovery May Prove Invaluable In Quest For Gene Therapies
    Scientists identified how a protein enables sections of so-called junk DNA to be cut and pasted within genetic code – a finding which could speed development of gene therapies.
  • Smoking Causes Gene Damage in Minutes

    Smoking Causes Gene Damage in Minutes
    New findings should serve as a "stark warning" to those considering taking up cigarette smoking
  • Zoo's DNA Lab Cracks Cases Like CSI

    Zoo's DNA Lab Cracks Cases Like CSI
    Researchers at the Smithsonian's National Zoo's new genetics lab use animal DNA to diagnose new diseases, help in conservation efforts and solve mysteries.