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Texas declares independence from Mexico. They are unable to join the United States, though, because of the difference between slave and free states.
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Texas continually tried to join the US, but was constantly denied because it would once again bring the slavery problem to light.
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President James K. Polk is elected with the slogan 54 40 or Fight! in response to MAnifest Destiny
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John O'Sullivan coined the term "Manifest Destiny" in an essay on the admittence of Texas to the Union.
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See Mexican War timeline for more details. The United States gained Texas, California, and New Mexico.
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The Oregon Treaty is signed dividing the territory between the US and the UK at the 49th parrallel
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Gold was discovered in Claifornia by James W. Marshall. This inspired alot of immigration to the West.