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Napoleon Bonaparte dies on Saint Helena in the South Atlantic.
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The Monroe Doctrine was adopted which announced that the United States' prevention of further European colonization, abstaining from involvement in European politics, and stopping Europe's influence in the continent.
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The Bureau of Indian Affairs was created to replace the Office of Indian Trade. It was not recognized by Congress for quite a while.
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Uncle Tom's Cabin was published and helped inspire the anti-slavery movement.
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The Republican party was founded by the anti-slavery expansion activists.
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John Brown and his volunteers murdered five men that were settled on the Pottawatomie Creek in southeastern Kansas.
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Richard Henry Pratt and Sarah Mather open a school for Indian Children.
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U.S. Senate approved an agreement to lease Pearl Harbor in Hawaii as a naval base.
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The Dawes Act was regarding how the land was distributed to Native Americans in Oklahoma.