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The Powhatan Confederacy nearly wiped out the struggling Jamestown colony.
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Nathaniel Bacon along with a few others destroyed the Pamunkey Indians before leading an unsuccessful revolt against colonial authorities
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The american natives mostly joined in with the French but this conflict ended in 1763 with the Treaty of Paris.
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This prohibited American colonists from settling west of Appalachia due to settlers encroaching on the indian's lands.
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Little Turtle and Shawnee chief Tecumseh led the Miami and Shawnee people to resist white settlers in the western part of Ohio.
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The Black Hawk War was a brief conflict between the United States and Native Americans led by Black Hawk, a Sauk leader.
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Because of this war all but a few of the seminoles were wipes out.
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Indian regiments served with Confederate troops during the civil war.
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The Red River War was a military campaign launched by the United States Army in 1874 to displace the Native American tribes from the Southern Plains, and forcibly relocate the tribes to reservations in Indian Territory.