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The major cause of the Civil War was slavery , during the 1850's the north and the south clashed with opinions on how to handle the prospect. The Dred Scott v. Sanford debate over Kansas, Thomas Jefferson effectively helped to give more rights to the slaves, which went against what the southern constitution stood for- effectively resulting in a clash between the two regions.
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1.) The Dred Scott v. Sandford debate provoked a rift in the regions on whether or not slavery is constitutional.
2.) Thomas Jefferson helped the slaves in such ways by abolishing the slave trade.
3.) The South defended it's opinion on the role the "peculiar institution."