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Built by American electrical engineer Elisha Gray. He accidentally discovered the sound generation from a self-vibrating electromagnetic circuit, then he invented a basic single-note oscillator.
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The Teleharmonium added the capability of addative synthesis.
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Lee De Forest's invention allowed the construction of many other types of electronic instruments.
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Invented by Le De Forest
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Invented by Léon Theremin in 1920
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Invented by Maurice Martenot in 1928
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Invented by Friedrich Trautwein in 1929
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The Hammond Novachord released in 1939, was an electronic keyboard that used a frequency-divider for sound generation, with vibratos, filter, resonator-network and a dynamic envelope controller
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In the late 1940s, Canadian inventor and composer, Hugh Le Caine invented Electronic Sackbut, which provided the earliest realtime control of three aspects of sound (volume, pitch and timbre), corresponding to today's touch-sensitive keyboard, pitch & modulation controllers
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RCA developed the first programmable sound synthesizer, RCA Mark II Sound Synthesizer, and installed it to Columbia-Princeton Electronic Music Center in 1957.
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In 1961, Harald Bode wrote a paper exploring the concept of self-contained portable modular synthesizer using newly emerging transistor technology
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Robert Moog released the first commercially available modern synthesizer in 1965.