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The protests in Daraa have been continuing for several days, with a crackdown by security forces reportedly claiming some 60 lives up to now.
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The fighting spreads to Aleppo, the second-largest city in Syria and once its commercial hub
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In response to the unrelenting crackdown across the country, US President Barack Obama calls on Assad to resign and orders all Syrian government assets in the US to be frozen.
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A gas attack kills 26 people, at least half of them government soldiers, in the northern town of Khan al-Assal. A UN investigation concludes that sarin nerve gas was used, but cannot determine who used it. Both the government and the rebel forces accuse each other of using the prohibited gas.
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A far deadlier sarin gas attack kills hundreds in the rebel-held suburbs of Damascus. UN investigators determine that ground-to-ground missiles packed with sarin were fired into civilian areas while people slept. The US and others blame the Assad regime for the attack.
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The US launched limited airstrikes against "Islamic State" (IS) militants inside Syria.
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The Russian air force carries out relentless bombing attacks against Assad opponents and is also accused of deliberately bombing civilian targets, including hospitals. A civil war that had been deadlocked for four-and-a-half years begins to move steadily in favor of the Assad regime.
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At least 58 people are killed in what appears to be a nerve-gas attack on the town of Khan Sheikhoun in rebel-held Idlib province. Victims show telltale signs of a chemical weapons attack, including convulsions and foaming at the mouth.
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Trump approves military plans to arm the Kurdish YPG as part of the effort to retake the Syrian city of Raqqa from IS militants.
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Trump and Russian President Vladimir Putin agree to a limited ceasefire in three war-torn provinces in southwest Syria.
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Syrian warplanes bomb the suburbs of Damascus, just one day after the military had declared a cessation of hostilities in the area.