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The site of the mission was poorly chosen. The nearby Rio Grand flooded and changed course frequently. The adobe structures of the mission were severely damaged or swept away several times in the 1740s, 1829, and in the 1850s.
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Piro Indians from the Senecú Pueblo (south of Albuquerque, New Mexico) settled several leagues downriver from Guadalupe del Paso and a little northwest of the Tigua Indians of Ysleta del Sur Pueblo. The mission was dedicated to San Antonio de Padua.
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the mission was moved in 1726 to serve the Tamique and Aranama Indians in Mission Valley. Although successful
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San Francisco de los Tejas was the first mission built in the Spanish state of Texas. (There are earlier missions in what is now west Texas, but those missions were built the land was in Mexico.)
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Mission San Francisco Xavier de Horcasitas was the first of three missions built on the San Gabriel river, then known as the San Xavier.
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The mission was established, 4 miles west of La Bahia, in November 1754 by Father Juan de Dios Camberos to minister to the Karankawan tribes. The mission developed a large ranching system, but in 1781 the livestock was transferred
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Señora de Guadalupe was founded in 1756 in central Texas to serve the local Waco and Tonkawa tribes, congregating near the headwaters of the Comal river.
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The little-known Mission Nuestra Señora de la Luz was established in 1756 on the east bank of the Trinity River, near the site of present-day Wallisville. The original mission was destroyed by the Karankawa natives, and relocated farther North.
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Mission Nuestra Señora del Refugio was the final Spanish mission built in Texas. It was founded in February 1793 near the present day town of Long Mott .
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Mission San Antonio de Valero (The Alamo) was established on May 1, 1718 as the first Spanish mission along the San Antonio River.