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The first "calculator" was invented by Bell Telephone Laboratories by inventor George Stibitz. This is significant because this is the first time someone could use a machine to do a thing that you would ususally do, which is essentially what a computer is.
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Maurice Wilkes created the EDSAC, the first practical stored-program computer. This was significant, because this lead to computers in the future getting smaller, and smaller.
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IBM shipped its first electronic computer. IBM sold 19 computers to research laboratories, aircraft companies, and the federal government. This is important because now companies got ahold of computers, and can really start utilizing them.
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The IBM 650 magnetic drum calculator was the first mass-produced computer. It sold 450 in one year. This is significant because it would appear that computers started being more and more common in the world, and this is essentially the start of that.
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Digital Equipment Corp. introduced the PDP-8, the first commercially sold successful minicomputer. This was the start of when everyone could own their own personal computer.
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The Alto was the first computer where you could plug in a mouse to it. This was the first of many, and now all computers have thers.
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Steve Wozniak designed the Apple I, a single-board computer that started whole Apple line of computers, which we all have now
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Apollo Computer unveiled the first work station, its DN100, offering more power than some minicomputers. Now a days, all major work places have workstations.
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Apple Computer launched the Macintosh, the first successful mouse-driven computer with a graphic user interface. Now all computers have a GUI, and this was the first one.
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YouTube, the first video sharing site came online in 2005. After youtube came out, it is now the home of billions of videos.