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The first English established colony was formed in Jamestown, Virginia.
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The war started because Jamestown was not able to sustain themselves, and pressured the local Indians for relief.
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The first Anglo-Powhatan War ended with a period of peace; the Peace of Pocahontas, which included the marriage between Pocahontas and John Rolfe, as well as the Chickahominy Tribe becoming subjects of King James I.
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The Second Anglo-Powhatan War started due to Chief Opechancanough conducting a series of surprised attacks on English settlements, because Jamestown relied on the tobacco economy, which required a lot of land to grow the crop.
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The second war started when Powhatan Confederacy Chief Opechancanough initiated a surprise attack on an English colony. A temporary ceasefire was declared, but hostilities would continue to resume until a final peace was made.
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Colonists settled in what was then called Naumkeag in 1626, and under the leadership of Roger Conant, was able to survive for the first two years, but was replaced by John Endecott by order of the Massachusetts Bay Company.
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This war was over control of the fur and wampum trades in the Northeast.
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A group of English Puritans from Massachusetts Bay, Plymouth, and Connecticut colonies set a community of Pequot Native Americans on fire. This started the Pequot War.
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After 12 years of peace, the Powhatan Confederacy attempted to drive English settlers out of the Virginia Colony once more, resulting in the commissioning of three frontier forts, and the storming and capturing of Opechancanough. He died in captivity, killed by a settler assigned to guard him.
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The General Assembly of Virginia signed a peace treaty with the last chief of the Powhatan Confederacy, Necotowance, which bought an end to the Third Anglo-Powhatan War. The tribes of the Confederacy became tributaries to the King of England, paying a yearly tribute to the Virginia governor, and a racial frontier was delineated, forbidding settlers and Indians from crossing either side.