The Life and Travels of Christopher Columbus By kimmeadows1973 Aug 31, 1451 Christopher Columbus is born in Genoa. Period: Aug 31, 1451 to May 20, 1506 The Life and Travels of Christopher Columbus Nov 2, 1465 Columbus starts to sail at the age of 14. Aug 3, 1492 Columbus' 1st Voyage departs from Palos, Spain. Mar 15, 1493 Columbus returns to Spain Sep 7, 1493 The 2nd Voyage departs from Cadiz. May 30, 1496 The 3rd Voyage departs from Sanlucar, Spain. Jun 8, 1496 Columbus reaches the coast of Portugal. Oct 3, 1500 Columbus is arrested and sent home in chains. May 11, 1502 The 4th Voyage departs from Cadiz, Spain. Nov 7, 1504 Columbus returns to Spain. May 20, 1506 Columbus dies at Valladolid.